Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.
Ethanol
Grapefruit Juice
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Addison disease (adrenal gland problem) or
Alcohol abuse, or history of or
Brain tumor, history of or
Breathing or lung problems (eg, hypoxia, COPD, sleep apnea) or
Cancer of the esophagus or colon or
CNS depression or
Cor pulmonale (serious heart condition) or
Drug dependence, especially with narcotics, or history of or
Enlarged prostate (eg, BPH, prostatic hypertrophy) or
Gallbladder disease or gallstones or
Head injuries, history of or
Hypothyroidism (an underactive thyroid) or
Hypovolemia (low blood volume) or
Increased pressure in the head or
Kyphoscoliosis (curvature of the spine with breathing problems) or
Problems with passing urine or
Psychosis (mental disease) or
Stomach or bowel problems (eg, esophageal or colon cancer with a small gastrointestinal lumen) or
Trouble swallowing or
Weakened physical condition—Use with caution. May increase risk for more serious side effects.
Asthma, acute or severe or
Respiratory depression (serious breathing problem) or
Stomach or bowel blockage (including paralytic ileus)—Should not be used in patients with these conditions.
Hypotension (low blood pressure) or
Pancreatitis (swelling of the pancreas) or
Seizures, history of—Use with caution. May make these conditions worse.
Kidney disease, severe or
Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper Use
Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).
It is very important that you understand the rules of the Opioid Analgesic REMS program to prevent addiction, abuse, and misuse of oxycodone. This medicine should also come with a Medication Guide and a patient information leaflet. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. Ask your doctor if you have any questions.
Oxycodone extended-release capsules or tablets should only be used by patients who have already been taking narcotic pain medicines, also called opioids. These patients are called opioid-tolerant. If you are uncertain whether or not you are opioid-tolerant, check with your doctor before using this medicine.
Measure the oral liquid concentrate with the calibrated dropper that comes with the package. Your doctor may have you mix the concentrate with a small amount of liquid or food. Carefully follow the instructions and take the medicine mixture right away.
Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.
Swallow the Oxaydo® or OxyContin® tablet whole with water. Do not break, crush, cut, chew, or dissolve it. Do not pre-soak, lick, or wet the tablet before placing it in the mouth. Take one tablet at a time. Also, do not give this medicine through nasogastric or feeding tubes.

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